Significantly higher polybrominated diphenyl ether levels in young U.S. children than in their mothers.

While young children are rarely included in biomonitoring studies, they are presumed to be at greater risk of ingesting environmental contaminants-particularly those that accumulate in foods or shed from consumer products. The widely used fire retardants polybrominated diphenyl ethers (PBDEs) are ubiquitous contaminants in the indoor environment and are widely detected at higher levels in Americans than in individuals from other countries. However, there are only three studies of PBDEs in U.S. children. We hypothesized that PBDEs are present in higher concentrations in young children than their mothers. PBDEs were assessed in blood samples collected concurrently from 20 mothers and their children, ages 1.5 to 4 years. The chemical analyses were performed by GC/MS applying selected ion monitoring. The samples were analyzed for 20 PBDE congeners; 11 were detected. SigmaPBDEs for children were typically 2.8 times higher than for mothers, with median child:mother ratios varying from 2 to 4 for individual congeners. In 19 of 20 families studied, children had higher SigmaPBDE concentrations than their mothers with significant (p < 0.01) concentration differences for five of the PBDE congeners. Decabromodiphenyl ether (BDE-209) was quantitated in 13 children and 9 mothers. Other studies indicate PBDEs are not elevated at birth, suggesting that early life is an intense period of PBDE intake. Children's increased hand-to-mouth activity, dietary preferences, and exposures from breast milk may result in greater ingestion of PBDEs than adults. These findings suggest that measurements from adults likely do not reflect exposures to young children despite sharing homes and similar diets.

An analysis of candidates for addition to the Clean Air Act list of hazardous air pollutants.

There are 188 air toxics listed as hazardous air pollutants (HAPs) in the Clean Air Act (CAA), based on their potential to adversely impact public health. This paper presents several analyses performed to screen potential candidates for addition to the HAPs list. We analyzed 1086 HAPs and potential HAPs, including chemicals regulated by the state of California or with emissions reported to the Toxics Release Inventory (TRI). HAPs and potential HAPs were ranked by their emissions to air, and by toxicity-weighted (tox-wtd) emissions for cancer and noncancer, using emissions information from the TRI and toxicity information from state and federal agencies. Separate consideration was given for persistent, bioaccumulative toxins (PBTs), reproductive or developmental toxins, and chemicals under evaluation for regulation as toxic air contaminants in California. Forty-four pollutants were identified as candidate HAPs based on three ranking analyses and whether they were a PBT or a reproductive or developmental toxin. Of these, nine qualified in two or three different rankings (ammonia [NH3], copper [Cu], Cu compounds, nitric acid [HNO3], N-methyl-2-pyrrolidone, sulfuric acid [H2SO4], vanadium [V] compounds, zinc [Zn], and Zn compounds). This analysis suggests further evaluation of several pollutants for possible addition to the CAA list of HAPs.